Targeting Accuracy and Clinical Outcomes of Awake versus Asleep Interventional Magnetic Resonance Imaging-Guided Deep Brain Stimulation for Parkinson's Disease: The University of California, San Francisco Experience

• Published in: Neurosurgery Vol. 91; no. 5; p. 717
• Main Authors: Lee, Anthony T, Han, Kasey J, Nichols, Noah, Sudhakar, Vivek R, Burke, John F, Wozny, Thomas A, Chung, Jason E, Volz, Monica M, Ostrem, Jill L, Martin, Alastair J, Larson, Paul S, Starr, Philip A, Wang, Doris D
• Format: Journal Article
• Language: English
• Published: United States 01.11.2022
• Subjects: Deep Brain Stimulation - methods; Humans; Levodopa - therapeutic use; Magnetic Resonance Imaging, Interventional; Parkinson Disease - diagnostic imaging; Parkinson Disease - therapy; San Francisco; Treatment Outcome; Wakefulness; San Francisco
• ISSN: 1524-4040
• DOI: 10.1227/neu.0000000000002111

Interventional MRI (iMRI)-guided implantation of deep brain stimulator (DBS) leads has been developed to treat patients with Parkinson's disease (PD) without the need for awake testing. Direct comparisons of targeting accuracy and clinical outcomes for awake stereotactic with asleep iMRI-DBS for PD are limited. We performed a retrospective review of patients with PD who underwent awake or iMRI-guided DBS surgery targeting the subthalamic nucleus or globus pallidus interna between 2013 and 2019 at our institution. Outcome measures included Unified Parkinson's Disease Rating Scale Part III scores, levodopa equivalent daily dose, radial error between intended and actual lead locations, stimulation parameters, and complications. Of the 218 patients included in the study, the iMRI cohort had smaller radial errors (iMRI: 1.27 ± 0.72 mm, awake: 1.59 ± 0.96 mm, P < .01) and fewer lead passes (iMRI: 1.0 ± 0.16, awake: 1.2 ± 0.41, P < .01). Changes in Unified Parkinson's Disease Rating Scale were similar between modalities, but awake cases had a greater reduction in levodopa equivalent daily dose than iMRI cases ( P < .01), which was attributed to the greater number of awake subthalamic nucleus cases on multivariate analysis. Effective clinical contacts used for stimulation, side effect thresholds, and complication rates were similar between modalities. Although iMRI-DBS may result in more accurate lead placement for intended target compared with awake-DBS, clinical outcomes were similar between surgical approaches. Ultimately, patient preference and surgeon experience with a given DBS technique should be the main factors when determining the "best" method for DBS implantation.