Cytotoxicities and anti-herpes simplex virus activities of diterpenes isolated from Euphorbia species

The cytotoxicities of nine diterpene polyesters obtained from Euphorbia species were assayed by measuring their effects on the growth of Vero cells. Their antiviral effects on the multiplication of Herpes simplex virus type 2 (HSV-2) were studied by using the virus yield reduction method in cell cul...

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Published inPlanta medica Vol. 67; no. 7; p. 672
Main Authors Mucsi, I, Molnár, J, Hohmann, J, Rédei, D
Format Journal Article
LanguageEnglish
Published Germany 01.10.2001
Subjects
Animals
Antiviral Agents - chemistry
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Cercopithecus aethiops
Cytotoxins - chemistry
Cytotoxins - pharmacology
Cytotoxins - toxicity
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
Diterpenes - toxicity
Euphorbia - chemistry
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Extracts - toxicity
Vero Cells
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Summary:The cytotoxicities of nine diterpene polyesters obtained from Euphorbia species were assayed by measuring their effects on the growth of Vero cells. Their antiviral effects on the multiplication of Herpes simplex virus type 2 (HSV-2) were studied by using the virus yield reduction method in cell cultures. With the exception of the strongly cytotoxic 2alpha,5alpha,14beta-triacetoxy-3beta-benzoyloxy-8alpha,15beta-dihydroxy-7beta-isobutanoyloxy-9alpha-nicotinoyloxyjatropha-6(17),11E-diene (CC(50) 3.5 microg/ml), all the tested diterpenes exhibited a pronounced or moderate anti-herpes virus effect (IC(50) values between 2.5 and 8.3 microg/ml). The observed HSV-2 inhibitory activities were not associated with virucidal effects.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2001-17368