A current review of the antimicrobial activity of Hypericum perforatum L

A petrolether extract of the areal parts of Hypericum perforatum L. was reported to be active against gram-positive bacteria. Hyperforin, a phloroglucin derivative was shown to be the antimicrobial principle. Hyperforin exhibited an excellent effect against methicillin-resistant strains of Staphyloc...

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Bibliographic Details
Published inPharmacopsychiatry Vol. 34 Suppl 1; p. S116
Main Authors Reichling, J, Weseler, A, Saller, R
Format Journal Article
LanguageEnglish
Published Germany 01.07.2001
Subjects
Anti-Bacterial Agents - therapeutic use
Bridged Bicyclo Compounds
Humans
Hypericum
Phloroglucinol - analogs & derivatives
Plant Extracts - therapeutic use
Terpenes - therapeutic use
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Summary:A petrolether extract of the areal parts of Hypericum perforatum L. was reported to be active against gram-positive bacteria. Hyperforin, a phloroglucin derivative was shown to be the antimicrobial principle. Hyperforin exhibited an excellent effect against methicillin-resistant strains of Staphylococcus aureus with a MIC value of 1.0 microg/ml. A butanol fraction of St. John's Wort revealed anti-Helicobacter pylori activity with MIC values ranging between 15.6 and 31.2 microg/ml. Recently, hydrous solutions of Hypericum perforatum teas were found to be antimicrobially effective against gram-positive bacteria with special activity towards methicillin-restistant strains of Staphylococcus aureus (MIC values: 1.3 to 2.5 mg herb/ml).
ISSN:0176-3679
DOI:10.1055/s-2001-15514