CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas

Chaperonins, which contain t-complex polypeptide 1 (CCT), are critical for correct protein folding to generate stable and functional protein conformations, which are important for cell growth and survival. However, little is known about the expression and prognostic significance of CCT8 (subunit 8 o...

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Published inJournal of Cancer Vol. 14; no. 17; pp. 3238 - 3247
Main Authors Wu, Zhiqiang, Deng, Liyuan, Tao, Jin, Lu, Yuhai, Zeng, Xiaofei, Jia, Weikun, Chen, Hu
Format Journal Article
LanguageEnglish
Published Sydney Ivyspring International Publisher 01.01.2023
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Research Paper
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Summary:Chaperonins, which contain t-complex polypeptide 1 (CCT), are critical for correct protein folding to generate stable and functional protein conformations, which are important for cell growth and survival. However, little is known about the expression and prognostic significance of CCT8 (subunit 8 of the CCT complex chaperonin) in lung cancer. In this study, we demonstrated that CCT8 expression is frequently increased in human lung cancer. Survival analysis indicated that CCT8 expression is closely correlated with inferior overall survival in lung adenocarcinoma (LUAD), but not in lung squamous carcinoma (LUSC). Subsequently, ectopic expression of CCT8 facilitated cell migration and tumor metastasis, and vice versa. Mechanistically, CCT8 interacted and activated ATK. Inhibition of AKT suppressed CCT8-induced cell migration and tumor metastasis. Our findings support CCT8 as a biomarker for LUAD prognosis and as a target for LUAD therapy.
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Competing Interests: The authors have declared that no competing interest exists.
The authors contributed equally to this manuscript.
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.87983