Cerebellar Hypoplasia in Neonatal Rats Caused by Lymphocytic Choriomeningitis Virus

Lymphocytic choriomeningitis virus, strain E-350, when inoculated intracerebrally in rats 1 to 7 days old, produces an acute destructive infection of the cerebellar cortex resulting in permanent cerebellar hypoplasia and ataxia. Several other arenoviruses may produce a similar lesion in neonatal rod...

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Published inScience (American Association for the Advancement of Science) Vol. 171; no. 3967; pp. 194 - 196
Main Authors Monjan, Andrew A., Gilden, Donald H., Cole, Gerald A., Nathanson, Neal
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 15.01.1971
Subjects
Animals
Animals, Newborn
Antibodies
Ataxia - etiology
Blood plasma
Cerebellar Cortex - pathology
Cerebellar Diseases - etiology
Cerebellum
Demyelinating Diseases
Infections
Inoculation
Lesions
Lymphocytic Choriomeningitis - complications
Lymphocytic Choriomeningitis - pathology
Lymphocytic choriomeningitis virus
Lymphocytic choriomeningitis virus - pathogenicity
Necrosis
Rats
Viruses
Viruses, Unclassified - pathogenicity
Von Willebrand diseases
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Summary:Lymphocytic choriomeningitis virus, strain E-350, when inoculated intracerebrally in rats 1 to 7 days old, produces an acute destructive infection of the cerebellar cortex resulting in permanent cerebellar hypoplasia and ataxia. Several other arenoviruses may produce a similar lesion in neonatal rodents.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0036-8075
1095-9203
DOI:10.1126/science.171.3967.194