What Does Human Leukocyte Antigen B27 Have to Do with Spondyloarthritis?

Human leukocyte antigen (HLA) B27 is the key laboratory parameter for axial spondyloarthritis (axSpA). Its prevalence is variable across different geographic zones and ethnicities, and often mirrors the prevalence of axSpA. HLA-B27 plays a role in axSpA physiopathology. It is correlated with spondyl...

Full description

Saved in:
Bibliographic Details
Published inRheumatic diseases clinics of North America Vol. 46; no. 2; p. 225
Main Authors Fahed, Hanna, Mauro, Daniele, Ciccia, Francesco, Ziade, Nelly R
Format Journal Article
LanguageEnglish
Published United States 01.05.2020
Subjects
Genetics
Disease phenotype
Prognosis
Diagnosis
HLA-B27
Spondyloarthritis
Online AccessGet more information

Cover

More Information
Summary:Human leukocyte antigen (HLA) B27 is the key laboratory parameter for axial spondyloarthritis (axSpA). Its prevalence is variable across different geographic zones and ethnicities, and often mirrors the prevalence of axSpA. HLA-B27 plays a role in axSpA physiopathology. It is correlated with spondyloarthritis phenotype with a consistent positive association with family history, early disease onset, shorter diagnostic delay, hip involvement, and acute anterior uveitis. HLA-B27 has a pivotal role in many referral strategies. However, these strategies were developed in European populations and need to be evaluated in populations with lower HLA-B27 background prevalence, and where additional parameters might be needed.
ISSN:1558-3163
DOI:10.1016/j.rdc.2020.01.002