Jetting Dispenser Height Effect on the Accuracy of Test Strip for Blood Glucose

• Published in: Journal of medical and biological engineering Vol. 39; no. 1; pp. 109 - 116
• Main Authors: Kim, Kun-Yong, Lee, Yi-Cheng, Chang, Ho, Lee, Rahn-Fang, Wu, Hong-Wei
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 06.02.2019; Springer Nature B.V
• Subjects: Beads; Biomedical Engineering and Bioengineering; Blood; Cell Biology; Circuit boards; Coefficient of variation; Dispensers; Dispensing; Dispensing machines; Droplets; Engineering; Enzymes; Glucose; Glucose oxidase; Gold; Home medical tests; Imaging; Original Article; Radiology; Strip; Submerging; Weight; Jetting dispenser; Nozzle height; Blood glucose test strip; Standard deviation; Coefficient of variation; Biosensor
• ISSN: 1609-0985; 2199-4757
• DOI: 10.1007/s40846-018-0380-3

This study explores the application of Jetting Dispensers to dispense droplets of glucose oxidase enzyme solution onto blood test strips of immersion gold-plated printed circuit boards. Each droplet must contain the same weight of glucose oxidase enzyme solution, and the jetting dispensing must be within the reaction area of test strip while wrapping around the golden electrodes. Experimental results show that the height at which the droplets of glucose oxidase enzyme solution are jet dispensed onto the test strip reaction area significantly affects the glucose test strip. A dispensing machine with a jet dispensing height of 1.3 mm produces droplets in the test strip area that are all the shape of arc beads. Therefore, test strips have lower standard deviation (STD) and coefficient of variation (CV) when dispensed at 1.3 mm than at heights of 1.1 and 1.5 mm. This study confirms that the optimum jet dispensing height parameter with respect to enzyme compound is 1.3 mm.