Lack of differences in nef alleles among HIV-infected asymptomatic long-term survivors and those who progressed to disease

Sequences of the human immunodeficiency virus (HIV) nef gene in virus isolates from 12 long-term survivors (LTSs) and 7 progressors were compared to determine if any association existed between the sequences and the corresponding clinical status. The sequences of at least five clones were determined...

Full description

Saved in:
Bibliographic Details
Published inAIDS research and human retroviruses Vol. 15; no. 17; p. 1573
Main Authors Mourich, D V, Lee, S, Reyes-Teran, G, Mackewicz, C E, Levy, J A
Format Journal Article
LanguageEnglish
Published United States 20.11.1999
Subjects
Alleles
Base Sequence
Consensus Sequence
Disease Progression
Genes, nef - genetics
HIV - genetics
HIV Infections - diagnosis
HIV Infections - virology
HIV Long-Term Survivors
Humans
Molecular Sequence Data
Open Reading Frames - genetics
Online AccessGet more information

Cover

More Information
Summary:Sequences of the human immunodeficiency virus (HIV) nef gene in virus isolates from 12 long-term survivors (LTSs) and 7 progressors were compared to determine if any association existed between the sequences and the corresponding clinical status. The sequences of at least five clones were determined for each subject. Conceptual translations of the open reading frames (ORFs) were examined with respect to a consensus with a prototypic nef sequence (HIV-1SF2) and for conservation of functionally described motifs. Premature stops were observed at equivalent, yet low, frequencies among the different clinical groups: 2 of 60 (3.33%) and 1 of 45 (2.22%) respectively. No remarkable differences in protein motifs implicated in several activities ascribed to Nef were noted. An association between nef sequence characteristics and the clinical state was not found.
ISSN:0889-2229
DOI:10.1089/088922299309865