One-pot synthesis of highly hemocompatible polyurethane/polyethersulfone composite membranes

• Published in: Polymer bulletin (Berlin, Germany) Vol. 74; no. 9; pp. 3797 - 3818
• Main Authors: Wang, Chen, Wang, Qian, Li, Shuangsi, Zhang, Man, Zhao, Weifeng, Sun, Shudong, Zhao, Changsheng
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2017; Springer Nature B.V
• Subjects: Acids; Adsorption; Anticoagulants; Biocompatibility; Blood; Blood platelets; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Complex Fluids and Microfluidics; Contact angle; Crosslinking; Fourier transforms; Functional groups; Membranes; Morphology; Organic Chemistry; Original Paper; Physical Chemistry; Plasma; Polyethersulfones; Polymer Sciences; Polymerization; Polyurethane resins; Protein adsorption; Proteins; Scanning electron microscopy; Soft and Granular Matter; Spectrum analysis; Thromboplastin; United States > US; China; Germany; Activate Partial Thromboplastin Time; Composite Membrane; Atom Transfer Radical Polymerization; Water Contact Angle; Platelet Adhesion
• ISSN: 0170-0839; 1436-2449
• DOI: 10.1007/s00289-017-1922-5

In this study, polyethersulfone (PES) membranes were modified by in situ cross-linking polymerization of polyurethane with functional groups of –COOH and –SO 3 H using PEG as the chain extender in one pot, followed with a phase inversion technique. The composite membranes were characterized by FTIR, water contact angle, and scanning electron microscope. Comparing with pristine PES membrane, the modified membranes showed decreased water contact angles and changed cross-sectional morphology. The modified membranes also showed decreased protein adsorption and suppressed platelet adhesion, as well as improved antifouling property. In addition, the composite membranes had prolonged activated partial thromboplastin times due to the functional groups and improved hydrophilicity. The results of contact activation and complement activation also indicated that the modified membranes had good blood compatibility. Furthermore, the cytocompatibility was significantly improved. The highly hemocompatible PES composite membranes fabricated by the in situ cross-linking polymerization of polyurethane may have great potential to be used in the field of blood purification.