Fly ash supported NiO as an efficient catalyst for the synthesis of xanthene and its molecular docking study against plasmodium glutathione reductase

• Published in: Research on chemical intermediates Vol. 44; no. 12; pp. 7459 - 7478
• Main Authors: Borhade, Ashok V., Tope, Dipak R., Kushare, Sachin S., Thakare, Savita V.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2018; Springer Nature; Springer Nature B.V
• Subjects: Catalysis; Catalysts; Chemical synthesis; Chemistry; Chemistry and Materials Science; Chemistry, Multidisciplinary; Fly ash; Fourier transforms; Glutathione; Infrared spectroscopy; Inorganic Chemistry; Molecular docking; Nanocomposites; Nickel oxides; Physical Chemistry; Physical Sciences; Scanning electron microscopy; Science & Technology; X ray spectra; X-ray diffraction; Fly ash; Docking; Xanthene derivatives; FA–NiO nanocomposite; Glutathione reductase; OXIDATION; FA-NiO nanocomposite; COMBUSTION; ACETYLATION; PERFORMANCE; SODALITE; GREEN; ALCOHOLS; NANOPARTICLES; HETEROGENEOUS CATALYST; DERIVATIVES
• ISSN: 0922-6168; 1568-5675
• DOI: 10.1007/s11164-018-3567-x

A novel fly ash supported NiO (FA–NiO) nanocomposite solid heterogeneous catalyst has been prepared by impregnation of Ni(NO 3 ) 2 · 6H 2 O on thermally activated fly ash (FA) support. FT-IR spectroscopy, X-ray diffraction analysis, scanning electron microscopy, TEM and BET techniques were employed to characterize the catalyst. The catalytic adeptness of FA–NiO was tested and optimized in xanthene formation. Catalyst gave very high yield and good purity. Stability of the catalyst could be promising as it easily recovered and reused giving a similar yield up to four cycles. FA–NiO is an efficient catalyst providing an environmentally clean process for xanthene formation and for developing a revolutionary way to use the majority of waste fly ash. Further, we have also performed docking simulation between 1ONF and a xanthene molecule to evaluate binding orientation and affinity of the ligand.