Preparation of ZnS:Ni/ZnS quantum dots with core/shell structure and application for detecting cefoperazone–sulbactam

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 121; pp. 350 - 354
• Main Authors: Qu, Jianying, Zhu, Zhuanying, Wu, Changda, Zhang, Lianjie, Qu, Jianhang
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 2014
• Subjects: Buffers; Calibration; Cefoperazone; Cefoperazone - analysis; Hydrogen-Ion Concentration; Nickel - chemistry; Quantum Dots; Spectrometry, Fluorescence; Spectrophotometry, Atomic; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Sulbactam; Sulbactam - analysis; Sulfides - chemistry; Thermogravimetry; X-Ray Diffraction; Zinc Compounds - chemistry; Quantum dots; Sulbactam; Cefoperazone
• ISSN: 1386-1425; 1873-3557
• DOI: 10.1016/j.saa.2013.10.096

[Display omitted] •ZnS:Ni/ZnS QDs were synthesized easily with nontoxic.•It shows fluorescent characteristic with good water-solubility and stability.•ZnS:Ni/ZnS QDs was firstly used as fluorescent probe to detect CPZ–SBT.•This novel method is sensitive with good selectivity and a low detection limit. ZnS:Ni quantum dots (QDs) have been synthesized via a water-soluble route, which were coated by ZnS shell through surface modification to give ZnS:Ni/ZnS QDs. The QDs were characterized by atomic force microscope, X-ray diffraction, infrared spectrometry and fluorescent spectrometry. Then, a novel method for the determination of cefoperazone–sulbactam (CPZ–SBT) in aqueous solutions has been developed based on the enhancement of fluorescence of ZnS:Ni/ZnS QDs in the presence of CPZ–SBT. Under the optimal conditions, the enhanced fluorescence intensity (ΔF) was proportional to CPZ–SBT concentration in the range of 8.0×10−6–1.0×10−4g/L with a detection limit of 1.0×10−7g/L. The method was employed for the determination of CPZ–SBT in sample to give satisfactory result. Compared with others, this method was more sensitive, fast and simple with low limit detection.