The prognostic value of plasma thrombospondin-1 concentrations after aneurysmal subarachnoid hemorrhage

• Published in: Clinica chimica acta Vol. 448; pp. 155 - 160
• Main Authors: Shen, Yong-Feng, Wang, Wen-Hong, Yu, Wen-Hua, Dong, Xiao-Qiao, Du, Quan, Yang, Ding-Bo, Wang, Hao, Jiang, Li, Du, Yuan-Feng, Zhang, Zu-Yong, Zhu, Qiang, Che, Zhi-Hao, Liu, Qun-Jie
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.08.2015
• Subjects: Adult; Enzyme-Linked Immunosorbent Assay; Female; Humans; Intracranial aneurysmal; Male; Multivariate Analysis; Prognosis; Prospective Studies; Risk Factors; Severity; Subarachnoid hemorrhage; Subarachnoid Hemorrhage - blood; Subarachnoid Hemorrhage - diagnosis; Thrombospondin 1 - blood; Thrombospondin-1; Thrombospondin-1; Intracranial aneurysmal; Severity; Prognosis; Subarachnoid hemorrhage
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2015.06.024

Thrombospondin-1 is a homotrimeric glycoprotein with well known functions in hemostasis and angiogenesis. Its expression was increased after experimental intracerebral hemorrhage. We determined whether increased plasma thrombospondin-1 concentrations are predictive of clinical outcomes of aneurysmal subarachnoid hemorrhage (aSAH). Plasma thrombospondin-1 concentrations of 118 aSAH patients and 118 age- and gender-matched healthy controls were determined using enzyme-linked immunosorbent assay. Patients were followed up until death or completion of 6months after aSAH. An unfavorable outcome was defined as Glasgow Outcome Scale score of 1–3. Multivariate analyses of significant variables of univariate analyses were performed to determine independent risk factors for the clinical outcomes. Plasma thrombospondin-1 concentrations were significantly higher in aSAH patients than in healthy controls; plasma thrombospondin-1 concentrations were independently associated with clinical severity reflected by the World Federation of Neurological Surgeons score and Fisher score; thrombospondin-1 was identified as an independent predictor of 6-month mortality and 6-month unfavorable outcome; thrombospondin-1 had similar predictive performance compared with the World Federation of Neurological Surgeons score and Fisher score according to receiver operating characteristic curve analysis. Higher plasma thrombospondin-1 concentrations are associated with clinical severity and long-term prognosis of aSAH patients. •Plasma thrombospondin-1 levels are elevated after aneurysmal subarachnoid hemorrhage.•Plasma thrombospondin-1 levels are highly associated with the severity of aneurysmal subarachnoid hemorrhage.•Plasma thrombospondin-1 levels independently predict clinical outcomes of aneurysmal subarachnoid hemorrhage.•Plasma thrombospondin-1 levels have high predictive values for clinical outcomes of aneurysmal subarachnoid hemorrhage.