A "light-up" and "spectrum-shift" response of aptamer-functionalized silver nanoclusters for intracellular mRNA imaging

We have designed a novel multifunctional DNA scaffold for the synthesis of fluorescent silver nanoclusters (Ag NCs) using a one-pot approach. The obtained DNA/Ag NCs presented a "light-up" and "spectrum-shift" response to target DNA in vitro and could further image the tumor-rela...

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Published inChemical communications (Cambridge, England) Vol. 50; no. 54; pp. 7107 - 7110
Main Authors Li, Jingjing, You, Jia, Zhuang, Yinping, Han, Cuiping, Hu, Junfeng, Wang, Aming, Xu, Kai, Zhu, Jun-Jie
Format Journal Article
LanguageEnglish
Published England 11.07.2014
Subjects
Animals
Aptamers, Nucleotide - chemistry
Cell Survival - drug effects
Deoxyribonucleic acid
Diagnostic Imaging
Fluorescent Dyes - chemistry
HeLa Cells
Humans
Imaging
Mice
Nanostructure
Nanostructures - chemistry
NIH 3T3 Cells
RNA, Messenger - analysis
Scaffolds
Silver
Silver - chemistry
Synthesis
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Summary:We have designed a novel multifunctional DNA scaffold for the synthesis of fluorescent silver nanoclusters (Ag NCs) using a one-pot approach. The obtained DNA/Ag NCs presented a "light-up" and "spectrum-shift" response to target DNA in vitro and could further image the tumor-related mRNA in living cells.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc00160e