Effects of RAD50 SNP, sodium intake, and H. pylori infection on gastric cancer survival in Korea

• Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Vol. 27; no. 2; pp. 210 - 220
• Main Authors: Kwak, Jung Hyun, Eun, Chang Soo, Han, Dong Soo, Kim, Hyun Ja
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.03.2024; Springer Nature B.V
• Subjects: Abdominal Surgery; Cancer Research; Case-Control Studies; Cell activation; Cell cycle; DNA damage; DNA repair; Double-strand break repair; Fatalities; Gastric cancer; Gastroenterology; Health risks; Helicobacter Infections - complications; Helicobacter Infections - genetics; Helicobacter pylori; Homozygotes; Humans; Infections; Medical records; Medicine; Medicine & Public Health; Meiosis; Mortality; Oncology; Original Article; Patients; Polymorphism; RAD50 gene; Regression analysis; Republic of Korea - epidemiology; Risk Factors; Single-nucleotide polymorphism; Sodium; Sodium, Dietary; Stomach Neoplasms - complications; Surgical Oncology; Survival analysis; Telomeres; Republic of Korea; infection; Sodium intake; Gastric cancer; Survival; RAD50 SNP; H. pylori infection
• ISSN: 1436-3291; 1436-3305
• DOI: 10.1007/s10120-023-01441-x

Background Double-strand break repair protein ( RAD50 ) gene plays important roles in genomic integrity, DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. The risk allele of RAD50 may negatively affect cancer by reducing the DNA repair capacity. Additionally, Sodium intake and  Helicobacter pylori (H. pylori) infection are major risk factors for gastric cancer (GC). Our study investigated the association between polymorphisms in RAD50 gene and the risk of GC case-fatality. We evaluated whether the association differed with sodium intake or H. pylori infection. Methods We enrolled 490 patients from two hospitals between 2002 and 2006. Their survival or death was prospectively followed up until December 31, 2016, through a review of medical records and telephone surveys. The GC survival was assessed using the Cox proportional hazards regression analysis. Results In 319 GC cases, the total person-years were 1928.3, and the median survival years was 5.4 years. A total of 137 GC deaths were recorded. Our fully adjusted model showed that the GG type of RAD50 rs17772583 polymorphism is significantly associated with an increased risk of GC case-fatality (hazard ratio [HR] = 2.20, 95% confidence interval [CI] = 1.28–3.77) compared to that associated with the homozygous AA type. In the high sodium intake group, patients with the GG type of RAD50 rs17772583 showed a significantly higher GC case-fatality (HR = 8.61, 95% CI = 2.58–26.68) than that of patients with homozygous AA type. In the positive- H. pylori infection group, patients with GG-type RAD50 rs17772583 showed a significantly higher GC case-fatality (HR = 10.11, 95% CI = 2.81–36.35) than that of with AA homozygotes. Conclusions Patients with GG-type RAD50 rs17772583 , high sodium intake, or a positive- H. pylori infection are at a significantly increased risk of GC case-fatality compared to that associated with the absence of these risk factors.