Myocardial ischemia-reperfusion injury; Molecular mechanisms and prevention

• Published in: Microvascular research Vol. 149; p. 104565
• Main Authors: Liu, Yang, Li, Lei, Wang, Zhen, Zhang, Juan, Zhou, Zhou
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2023
• Subjects: Heart Failure; Humans; Molecular mechanisms; Myocardial Infarction; Myocardial ischemia-reperfusion injury; Myocardial Reperfusion Injury - metabolism; Prevention; Prevention; Myocardial ischemia-reperfusion injury; Molecular mechanisms
• ISSN: 0026-2862; 1095-9319
• DOI: 10.1016/j.mvr.2023.104565

Cardiovascular diseases are one of the leading causes of mortality in developed countries. Among cardiovascular disorders, myocardial infarction remains a life-threatening problem predisposing to the development and progression of ischemic heart failure. Ischemia/reperfusion (I/R) injury is a critical cause of myocardial injury. In recent decades, many efforts have been made to find the molecular and cellular mechanisms underlying the development of myocardial I/R injury and post-ischemic remodeling. Some of these mechanisms are mitochondrial dysfunction, metabolic alterations, inflammation, high production of ROS, and autophagy deregulation. Despite continuous efforts, myocardial I/R injury remains a major challenge in medical treatments of thrombolytic therapy, heart disease, primary percutaneous coronary intervention, and coronary arterial bypass grafting. The development of effective therapeutic strategies to reduce or prevent myocardial I/R injury is of great clinical significance.