Syntheses, Crystal Structures and Biological Activity of the 1D Chain Benzyltin Complexes Based on 2-Oxo-Propionic Acid Benzoyl Hydrazone

• Published in: Journal of inorganic and organometallic polymers and materials Vol. 27; no. 1; pp. 342 - 352
• Main Authors: Tan, Yu-Xing, Zhang, Zhi-Jian, Feng, Yong-Lan, Yu, Jiang-Xi, Zhu, Xiao-Ming, Zhang, Fu-Xing, Kuang, Dai-Zhi, Jiang, Wu-Jiu
• Format: Journal Article
• Language: English
• Published: New York Springer US 2017; Springer Nature B.V
• Subjects: Anticancer properties; Biological activity; Biotechnology; Chains; Chemical analysis; Chemical compounds; Chemical synthesis; Chemistry; Chemistry and Materials Science; Crystal structure; Dichlorides; Fluorescent indicators; Hydrazones; Inorganic Chemistry; NMR; Nuclear magnetic resonance; Optimization; Organic Chemistry; Polymer Sciences; Propionic acid; Single crystals; Synthesis; Hydrazone; Organotin; Biological activity; Crystal structure
• ISSN: 1574-1443; 1574-1451
• DOI: 10.1007/s10904-016-0477-5

Two new 1D Chain benzyltin complexes {[C 6 H 4 (O)C=N–N=C(Me)COO](CH 3 OH)(C 6 H 5 CH 2 ) 2 Sn} n ( 1 ), {[C 6 H 4 (O)C–NH–N=C(Me)COO](C 6 H 5 CH 2 ) 3 Sn} n ( 2 ) were synthesized by the reactions of 2-oxo-propionic acid benzoyl hydrazone with dibenzyltin dichloride or tribenzyltin chloride, respectively. The two complexes were characterized by FT-IR, 1 H, 13 C and 119 Sn NMR spectra, elemental analysis, X-ray single crystal diffraction and TGA. In vitro antitumor activities of both complexes were evaluated by the 3-(4,5-dimethylthiazoly-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against three human cancer cell lines (NCI-H460, HepG2, MCF7) and human cell line (HL7702). The 1 exhibited strong antitumor activity than 2 , then it was expected after further chemical optimization of candidate compounds as anti-cancer drugs. The interaction between complexes and calf thymus DNA were studied by EB fluorescent probe, the interaction of 1 and 2 with calf thymus DNA were intercalation and electrostatic attraction.