Interaction of the chlorite-based drug WF10 and chlorite with hemoglobin, methemoglobin and ferryl hemoglobin

• Published in: Archives of biochemistry and biophysics Vol. 585; pp. 82 - 89
• Main Authors: Pichert, Annelie, Arnhold, Jürgen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2015
• Subjects: Cells, Cultured; Chlorides - chemistry; Chlorine - chemistry; Chlorite; Erythrocytes - chemistry; Ferryl hemoglobin; Heme - chemistry; Hemoglobins - antagonists & inhibitors; Hemoglobins - chemistry; Hemolysis; Humans; Hydrogen Peroxide - chemistry; Kinetics; Methemoglobin; Methemoglobin - chemistry; Oxidation-Reduction; Oxides - chemistry; Oxyhemoglobin; Spectrophotometry; WF10; Hemolysis; Methemoglobin; Chlorite; Oxyhemoglobin; Ferryl hemoglobin; WF10

The interaction of the chlorite-based drug solution WF10 with human oxyhemoglobin and oxidized hemoglobin forms was investigated monitoring the corresponding spectral changes in heme states. The chlorite component of WF10 converts oxyhemoglobin into methemoglobin with a rate of 35.4 M−1s−1. Methemog...