Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase

• Published in: Mechanisms of ageing and development Vol. 138; pp. 53 - 58
• Main Authors: Zhao, Wei, Fang, Bing Xiong, Niu, Yu Jie, Liu, Yi Na, Liu, Bin, Peng, Qi, Li, Jiang Bin, Wasko, Brian M., Delaney, Joseph R., Kennedy, Brian K., Suh, Yousin, Zhou, Zhong Jun, Kaeberlein, Matt, Liu, Xin Guang
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.06.2014
• Subjects: Animals; Cytosol - metabolism; Herbicides - metabolism; Herbicides - pharmacology; Hydrogenase - metabolism; Iron-Sulfur Proteins - deficiency; Iron-Sulfur Proteins - metabolism; Lifespan; Mitochondria - metabolism; Mitochondrial superoxide dismutase; Nar1; Oxidative Stress - physiology; Paraquat - metabolism; Paraquat - pharmacology; Saccharomyces cerevisiae - physiology; Saccharomyces cerevisiae - ultrastructure; Saccharomyces cerevisiae Proteins - metabolism; Superoxide Dismutase - metabolism; Time Factors; Mitochondrial superoxide dismutase; Lifespan; Nar1

•Yeast Nar1 deficiency results in shortened lifespan and sensitivity to paraquat.•Nar1 deficiency cells have decreased aconitase activity and lower SOD2 mRNA level.•Overexpression of SOD2 suppresses defects associated with Nar1-deficiency in yeast. Saccharomyces cerevisiae Nar1p is an essential Fe/S...