Macrophage migration inhibitory factor levels in serum from patients with acute intracerebral hemorrhage: Potential contribution to prognosis

• Published in: Clinica chimica acta Vol. 472; pp. 58 - 63
• Main Authors: Lin, Qun, Cai, Jian-Yong, Lu, Chuan, Sun, Jun, Ba, Hua-Jun, Chen, Mao-Hua, Chen, Xian-Dong, Dai, Jun-Xia, Lin, Jian-Hu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2017
• Subjects: Acute Disease; Aged; Aged, 80 and over; Cerebral Hemorrhage - blood; Cerebral Hemorrhage - diagnosis; Female; Humans; Inflammation; Intracerebral hemorrhage; Macrophage migration inhibitory factor; Macrophage Migration-Inhibitory Factors - blood; Male; Middle Aged; Prognosis; Severity; Survival Analysis; NIHSS; OR; Prognosis; CI; ROC; HR; Inflammation; Severity; MIF; IQR; Intracerebral hemorrhage; AUC; ICH; Macrophage migration inhibitory factor; CT
• ISSN: 0009-8981; 1873-3492; 1873-3492
• DOI: 10.1016/j.cca.2017.07.016

Intracerebral hemorrhage (ICH) pathophysiology involves inflammation. Macrophage migration inhibition factor (MIF), a pro-inflammatory cytokine, is related to prognosis of ischemic stroke. The aim of this study was to investigate whether serum MIF levels are associated with severity and outcomes in patients with acute ICH. We enrolled a total of 120 consecutive ICH patients and 120 healthy controls and sampled blood on admission and at study entry respectively. Enzyme-linked immunosorbent assay was used to quantify serum MIF levels. Serum MIF levels were higher in patients compared with controls and correlated with hematoma volume, National Institutes of Health Stroke Scale (NIHSS) scores and plasma C-reactive protein levels. After adjusting for other significant outcome predictors, MIF in serum was an independent predictor of 6-month overall survival and unfavorable outcome (modified Rankin Scale score >2). Areas under receiver-operating characteristic curve (ROC) of serum MIF levels, hematoma volume and NIHSS scores were similar for 6-month unfavorable outcome. Moreover, serum MIF levels significantly improved areas under ROC of hematoma volume and NIHSS scores. MIF in serum might be a potential biomarker for reflecting inflammation, severity and prognosis of ICH patients. •Serum macrophage migration inhibitory factor levels are elevated after intracerebral hemorrhage.•Serum macrophage migration inhibitory factor levels correlate with inflammation and severity.•Serum macrophage migration inhibitory factor levels independently predict clinical outcomes.•Serum macrophage migration inhibitory factor levels have high prognostic predictive values.