Targeting neutrophils in asthma: A therapeutic opportunity?

[Display omitted] Suppression of airway inflammation with inhaled corticosteroids has been the key therapeutic approach for asthma for many years. Identification of inflammatory phenotypes in asthma has moreover led to important breakthroughs, e.g. with specific targeting of the IL-5 pathway as add-...

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Bibliographic Details
Published inBiochemical pharmacology Vol. 182; p. 114292
Main Authors De Volder, Joyceline, Vereecke, Lars, Joos, Guy, Maes, Tania
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 01.12.2020
Subjects
Adrenal Cortex Hormones - administration & dosage
Animals
Asthma
Asthma - drug therapy
Asthma - immunology
Asthma - metabolism
Drug Delivery Systems - methods
Drug Delivery Systems - trends
Humans
Inflammation Mediators - antagonists & inhibitors
Inflammation Mediators - metabolism
Neutrophilic inflammation
Neutrophils - drug effects
Neutrophils - immunology
Neutrophils - metabolism
CXCL
IL
Neutrophilic inflammation
TSLP
CCL20
OSM
TNF
MMP9
MPO
DAMPs
Asthma
IFN
ILC3
NE
ROS
LTB4
CXCR
Th1
NET
Th17
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Summary:[Display omitted] Suppression of airway inflammation with inhaled corticosteroids has been the key therapeutic approach for asthma for many years. Identification of inflammatory phenotypes in asthma has moreover led to important breakthroughs, e.g. with specific targeting of the IL-5 pathway as add-on treatment in difficult-to-treat eosinophilic asthma. However, the impact of interfering with the neutrophilic component in asthma is less documented and understood. This review provides an overview of established and recent insights with regard to the role of neutrophils in asthma, focusing on research in humans. We will describe the main drivers of neutrophilic responses in asthma, the heterogeneity in neutrophils and how they could contribute to asthma pathogenesis. Moreover we will describe findings from clinical trials, in which neutrophilic inflammation was targeted. It is clear that neutrophils are important actors in asthma development and play a role in exacerbations. However, more research is required to fully understand how modulation of neutrophil activity could lead to a significant benefit in asthma patients with airway neutrophilia.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:0006-2952
1873-2968
DOI:10.1016/j.bcp.2020.114292