Facilitation of the Long-Term Store of Memory with Strychnine

Female mice (C57BL/6 strain), repeatedly administered strychnine sulfate for 10 days after exposure to a six-unit maze, showed significantly improved learning when trained again. This facilitation effect was not due to overall enhancement of learning ability and could not be attributed to retrograde...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 177; no. 4050; pp. 722 - 724
Main Authors Alpern, Herbert P., Crabbe, John C.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 25.08.1972
Subjects
Alleys
Animals
Control groups
Discrimination Learning - drug effects
Dosage
Educational administration
Female
Injections, Intraperitoneal
LSD
Mazes
Memory
Memory - drug effects
Memory trace
Mice
Mice, Inbred Strains
Strychnine - administration & dosage
Strychnine - pharmacology
Sulfates
Vehicles
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Summary:Female mice (C57BL/6 strain), repeatedly administered strychnine sulfate for 10 days after exposure to a six-unit maze, showed significantly improved learning when trained again. This facilitation effect was not due to overall enhancement of learning ability and could not be attributed to retrograde facilitation of consolidation processes.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.177.4050.722