Role of the neuroendocrine antimicrobial peptide catestatin in innate immunity and pain

Catestatin （CST） is a neuroendocrine peptide which is derived from the chromogranin A. It has been demonstrated that CST can affect a wide range of processes, such as innate immunity, inflammatory and autoimmune reactions, and several homeostatic regulations. Furthermore, CST is positive against sev...

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Bibliographic Details
Published inActa biochimica et biophysica Sinica Vol. 49; no. 11; pp. 967 - 972
Main Authors Deng, Zeyu, Xu, Changshui
Format Journal Article
LanguageEnglish
Published China 01.11.2017
Subjects
Bacterial Infections - prevention & control
Chemotaxis, Leukocyte
Chromogranin A - physiology
Humans
Immunity, Innate
Mast Cells - physiology
Monocytes - immunology
Pain - etiology
Peptide Fragments - physiology
antimicrocal peptides
catestatin
pain
innate immunity
monocyte chemotaxis
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Summary:Catestatin （CST） is a neuroendocrine peptide which is derived from the chromogranin A. It has been demonstrated that CST can affect a wide range of processes, such as innate immunity, inflammatory and autoimmune reactions, and several homeostatic regulations. Furthermore, CST is positive against several kinds of bacterial strains at micromolecular range, which shows its anti- microbial activity. Recently, the role of CST in acute and chronic pain has attracted much attention. In this review, we discussed the latest research findings of CST and its role in innate immunity and pain.
Bibliography:Catestatin （CST） is a neuroendocrine peptide which is derived from the chromogranin A. It has been demonstrated that CST can affect a wide range of processes, such as innate immunity, inflammatory and autoimmune reactions, and several homeostatic regulations. Furthermore, CST is positive against several kinds of bacterial strains at micromolecular range, which shows its anti- microbial activity. Recently, the role of CST in acute and chronic pain has attracted much attention. In this review, we discussed the latest research findings of CST and its role in innate immunity and pain.
31-1940/Q
catestatin, innate immunity, antimicrocal peptides, monocyta chemotaxis, pain
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1672-9145
1745-7270
DOI:10.1093/abbs/gmx083