The Outcome of Accidental Bacille Calmette-Guérin Overdose During Routine Neonatal Immunization

We report a retrospective study on outcome of 14 newborn infants who received 62.5 times the recommended dose of Bacille Calmette-Guérin for immunization. All infants then received high-dose isoniazid and rifampicin (20 mg/kg/d each) as preventive therapy for 6 months. All had mild local adverse rea...

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Bibliographic Details
Published inThe Pediatric infectious disease journal Vol. 40; no. 6; p. 588
Main Authors Greybe, Leonore, Morrison, July L, Schaaf, H Simon, Rabie, Helena, Cotton, Mark F
Format Journal Article
LanguageEnglish
Published United States 01.06.2021
Subjects
Accidents
Anti-Bacterial Agents
BCG Vaccine - administration & dosage
BCG Vaccine - adverse effects
Drug-Related Side Effects and Adverse Reactions
Humans
Infant, Newborn
Isoniazid - therapeutic use
Retrospective Studies
Rifampin - therapeutic use
Tuberculosis - drug therapy
Tuberculosis - prevention & control
Vaccination - adverse effects
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Summary:We report a retrospective study on outcome of 14 newborn infants who received 62.5 times the recommended dose of Bacille Calmette-Guérin for immunization. All infants then received high-dose isoniazid and rifampicin (20 mg/kg/d each) as preventive therapy for 6 months. All had mild local adverse reactions, a third resolving within 16 weeks and all by 6 months.
ISSN:1532-0987
DOI:10.1097/INF.0000000000003073