Ti3C2Tx Coated with TiO2 Nanosheets for the Simultaneous Detection of Ascorbic Acid, Dopamine and Uric Acid

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 12; p. 2915
• Main Authors: Jia, Dengzhou, Yang, Tao, Wang, Kang, Wang, Hongyang, Wang, Enhui, Chou, Kuo-Chih, Hou, Xinmei
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 19.06.2024; MDPI
• Subjects: Annealing; ascorbic acid; Carbon; Dopamine; Electrodes; Etching; Oxidation; Reproducibility; solvothermal; Ti3C2Tx; TiO2; Uric acid
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29122915

Two-dimensional MXenes have become an important material for electrochemical sensing of biomolecules due to their excellent electric properties, large surface area and hydrophilicity. However, the simultaneous detection of multiple biomolecules using MXene-based electrodes is still a challenge. Here, a simple solvothermal process was used to synthesis the Ti3C2Tx coated with TiO2 nanosheets (Ti3C2Tx@TiO2 NSs). The surface modification of TiO2 NSs on Ti3C2Tx can effectively reduce the self-accumulation of Ti3C2Tx and improve stability. Glassy carbon electrode was modified by Ti3C2Tx@TiO2 NSs (Ti3C2Tx@TiO2 NSs/GCE) and was able simultaneously to detect dopamine (DA), ascorbic acid (AA) and uric acid (UA). Under concentrations ranging from 200 to 1000 μM, 40 to 300 μM and 50 to 400 μM, the limit of detection (LOD) is 2.91 μM, 0.19 μM and 0.25 μM for AA, DA and UA, respectively. Furthermore, Ti3C2Tx@TiO2 NSs/GCE demonstrated remarkable stability and reliable reproducibility for the detection of AA/DA/UA.