Oral acyclovir in herpes zoster

Forty-one patients with herpes zoster were treated with acyclovir or placebo at a dosage of 400 mg five times a day by mouth for five days in a double-blind randomized domiciliary study. Acyclovir was shown to reduce the days of new lesion formation within the effected dermatome after day 0 (P = 0.0...

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Bibliographic Details
Published inJournal of antimicrobial chemotherapy Vol. 14; no. 6; p. 661
Main Authors McKendrick, M W, Care, C, Burke, C, Hickmott, E, McKendrick, G D
Format Journal Article
LanguageEnglish
Published England 01.12.1984
Subjects
Acyclovir - administration & dosage
Acyclovir - therapeutic use
Administration, Oral
Aged
Clinical Trials as Topic
Double-Blind Method
Female
Herpes Zoster - complications
Herpes Zoster - drug therapy
Humans
Male
Middle Aged
Pain - etiology
Placebos
Random Allocation
Time Factors
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Summary:Forty-one patients with herpes zoster were treated with acyclovir or placebo at a dosage of 400 mg five times a day by mouth for five days in a double-blind randomized domiciliary study. Acyclovir was shown to reduce the days of new lesion formation within the effected dermatome after day 0 (P = 0.049). No other statistical difference was demonstrated between the two groups although the trends for new lesion formation outside the dermatome, full crusting, involution and diminution of acute pain all favoured acyclovir.
ISSN:0305-7453
DOI:10.1093/jac/14.6.661