MIF-Like Activity in Simian Virus 40-Transformed 3T3 Fibroblast Cultures

Simian virus 40-transformed fibroblasts (SV3T3), as compared with their untransformed counterparts (3T3), elaborate a macromolecular product that inhibits macrophage migration and causes macrophages to aggregate and lose one type of cell coat material. The SV3T3 cells also lack this surface material...

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Published inScience (American Association for the Advancement of Science) Vol. 185; no. 4155; pp. 955 - 957
Main Authors Hammond, M. Elizabeth, Roblin, Richard O., Dvorak, Ann M., Selvaggio, Salvatore S., Black, Paul H., Dvorak, Harold F.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 13.09.1974
Subjects
3T3 cells
BALB 3T3 cells
Cell culture techniques
Cell Line
Cell lines
Cell Membrane - pathology
Cell Transformation, Neoplastic - pathology
Contact Inhibition
Cultured cells
Embryonic cells
Fibroblasts
Lymphocytes
Macrophage Migration-Inhibitory Factors - biosynthesis
Macrophages
Simian virus 40
Virions
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Summary:Simian virus 40-transformed fibroblasts (SV3T3), as compared with their untransformed counterparts (3T3), elaborate a macromolecular product that inhibits macrophage migration and causes macrophages to aggregate and lose one type of cell coat material. The SV3T3 cells also lack this surface material relative to 3T3 cells. There may be a relation between migration inhibition factor (MIF), the cell coat, and cell migration.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0036-8075
1095-9203
DOI:10.1126/science.185.4155.955