Transfer Factor: Delayed Hypersensitivity to Schistosoma mansoni and Tuberculin in Macaca mulatta

Delayed hypersensitivity in Macaca mulatta infected with either Schistosoma mansoni or mycobacteria was demonstrated by biopsies of skin test sites. Both dialyzable and nondialyzable leukocyte extracts from infected donors transferred delayed hypersensitivity to recipient monkeys. In two recipients,...

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Published inScience (American Association for the Advancement of Science) Vol. 178; no. 4062; pp. 757 - 759
Main Authors Maddison, Shirley E., Hicklin, Martin D., Conway, Brian P., Kagan, Irving G.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 17.11.1972
Subjects
Animals
Antigens
Antigens, Bacterial
Biopsies
Delayed hypersensitivity
Dialysis
Haplorhini
Hypersensitivity, Delayed
Immunity, Maternally-Acquired
Immunization
Immunization, Passive
Leukocytes
Lymphocyte Activation
Lymphocytes
Macaca
Mycobacterium - immunology
Mycobacterium bovis - immunology
Oysters
Reactivity
Schistosoma mansoni - immunology
Skin Tests
Tuberculin
Tuberculin Test
Viruses
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Summary:Delayed hypersensitivity in Macaca mulatta infected with either Schistosoma mansoni or mycobacteria was demonstrated by biopsies of skin test sites. Both dialyzable and nondialyzable leukocyte extracts from infected donors transferred delayed hypersensitivity to recipient monkeys. In two recipients, skin test conversion was associated with in vitro transformation of the recipients' lymphocytes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.178.4062.757