Physiologic Mechanisms of Weight Loss Following Metabolic/Bariatric Surgery

Bariatric and metabolic surgery has evolved from simple experimental procedures for a chronic problem associated with significant morbidity into a sophisticated multidisciplinary treatment modality rooted in biology and physiology. Although the complete mechanistic narrative of bariatric surgery can...

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Bibliographic Details
Published inThe Surgical clinics of North America Vol. 101; no. 2; p. 223
Main Authors Luo, James N, Tavakkoli, Ali
Format Journal Article
LanguageEnglish
Published United States 01.04.2021
Subjects
Bariatric Surgery - methods
Humans
Obesity - surgery
Postoperative Period
Weight Loss - physiology
Insulin resistance
Diabetes
Metabolism
Bariatric physiology
Bariatric surgery
Microbiome
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Summary:Bariatric and metabolic surgery has evolved from simple experimental procedures for a chronic problem associated with significant morbidity into a sophisticated multidisciplinary treatment modality rooted in biology and physiology. Although the complete mechanistic narrative of bariatric surgery cannot yet be written, significant advance in knowledge has been made in the past 2 decades. This article provides a brief overview of the most studied hypotheses and their supporting evidence. Ongoing research, especially in frontier areas, such as the microbiome, will continue to refine, and perhaps even revise, current mechanistic understanding.
ISSN:1558-3171
DOI:10.1016/j.suc.2020.12.006