Research progress on the role of lncRNA, circular RNA, and microRNA networks in regulating ferroptosis in osteosarcoma

• Published in: Biomedicine & pharmacotherapy Vol. 176; p. 116924
• Main Authors: Yan, Chunlu, Dou, Yinnan, Xia, Ruoliu, Liu, Shiqing, Fu, Jianchao, Li, Duo, Wang, Rong, Tie, Feng, Li, Linxin, Jin, Hua, An, Fangyu
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.07.2024; Elsevier
• Subjects: Animals; Bone Neoplasms - genetics; Bone Neoplasms - metabolism; Bone Neoplasms - pathology; Ferroptosis; Ferroptosis - genetics; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs - genetics; MicroRNAs - metabolism; Molecular mechanism; NcRNAs; Osteosarcoma; Osteosarcoma - genetics; Osteosarcoma - pathology; RNA, Circular - genetics; RNA, Circular - metabolism; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; NcRNAs; Ferroptosis; Osteosarcoma; Molecular mechanism
• ISSN: 0753-3322; 1950-6007; 1950-6007
• DOI: 10.1016/j.biopha.2024.116924

Noncoding RNAs (ncRNAs) do not participate in protein-coding. Ferroptosis is a newly discovered form of cell death mediated by reactive oxygen species and lipid peroxidation. Recent studies have shown that ncRNAs such as microRNAs, long noncoding RNAs, circular RNAs, and ferroptosis are involved in the occurrence and development of osteosarcoma (OS). Studies have confirmed that ncRNAs participate in the development of OS by regulating the ferroptosis. However, systematic summary on this topic are still lacking. This review summarises the potential role of ncRNAs in the diagnosis, treatment, drug resistance, and prognosis of OS and the basis for diagnosing, preventing, and treating clinical OS and developing effective drugs. This review summarises the latest research progress on ncRNAs that regulate ferroptosis in OS, attempts to clarify the molecular mechanisms by which ncRNAs regulate ferroptosis in the pathogenesis of OS, and elaborates on the involvement of ferroptosis in OS from the perspective of ncRNAs. [Display omitted] •NcRNAs play an important role in the treatment, diagnosis, prognosis, and drug resistance of osteosarcoma.•Ferroptosis involving ncRNAs provides a new direction for the pathogenesis of osteosarcoma.•NcRNAs may act as a hub for regulating the ferroptosis of osteosarcoma with other forms of cell metabolism and death.•The expression of ncRNAs related with ferroptosis is correlated with immune checkpoint, which can be explored as a new idea of immunotherapy for osteosarcoma.