Lipopolysaccharide (LPS) induced sickness in adolescent female rats alters the acute-phase response and lithium chloride (LiCl)- induced impairment of conditioned place avoidance/aversion learning, following a homotypic LPS challenge in adulthood

The multi-variable locomotor activity effects of LiCl treatment in female rats were examined in a conditioned place avoidance/aversion (CPA) paradigm. In addition, the sickness effects of an LPS injection (200 μg/kg), given during adolescents, on CPA learning in adulthood were examined, as were the...

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Published inBehavioural brain research Vol. 351; pp. 121 - 130
Main Authors Cloutier, Caylen J., Kavaliers, Martin, Ossenkopp, Klaus-Peter
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.10.2018
Subjects
Animals
Avoidance Learning
Avoidance/aversion
Conditioning (Psychology)
Female
Female rats
Illness Behavior
Infection - psychology
Lipopolysaccharide
Lipopolysaccharides
Lithium Chloride
Motor Activity
Place conditioning
Rats, Long-Evans
Sexual Maturation
Spatial Behavior
Tolerance effects
Female rats
Lipopolysaccharide
Tolerance effects
Place conditioning
Lithium chloride
Avoidance/aversion
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Summary:The multi-variable locomotor activity effects of LiCl treatment in female rats were examined in a conditioned place avoidance/aversion (CPA) paradigm. In addition, the sickness effects of an LPS injection (200 μg/kg), given during adolescents, on CPA learning in adulthood were examined, as were the effects of a homotypic LPS injection (200 μg/kg) just prior to CPA acquisition trials. Female rats were injected with LPS or saline during adolescents (6 weeks of age) and later pretreated with LPS again or saline in an automated two-chamber CPA paradigm with LiCl (95 mg/kg) treatments as the aversive toxin. Results showed that, while adolescent LPS treatment had no long-term effect on the establishment of CPA, it did interfere with the ability of a second LPS challenge in adulthood to impair CPA learning, an effect obtained in subjects pretreated with LPS in the CPA procedure in adulthood only. The results of this study demonstrate the importance of considering the adolescent stage of development when evaluating the effects of environmental challenges on adult behavior.
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ISSN:0166-4328
1872-7549
1872-7549
DOI:10.1016/j.bbr.2018.05.033