A novel borate fluorescent probe for rapid selective intracellular peroxynitrite imaging

[Display omitted] •A new type of fluorescent probe with benzyl borate was designed for monitoring ONOO–.•The probe was exhibited fast-response, high sensitivity towards ONOO–.•The probe has been used for biological imaging of exogenous and endogenous ONOO–. Peroxynitrite (ONOO–) is one of the specie...

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Published inSpectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 251; p. 119398
Main Authors Wang, Minmin, Wang, Chun, Song, Wenwu, Zhong, Weiting, Sun, Tongming, Zhu, Jinli, Wang, Jin
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 15.04.2021
Subjects
Benzyl borate
Borates
Cell imaging
Fast response
Fluorescent Dyes
Fluorescent probe
ONOO– detection
Optical Imaging
Peroxynitrous Acid
ONOO– detection
Cell imaging
Benzyl borate
Fast response
Fluorescent probe
ONOO(–) detection
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Summary:[Display omitted] •A new type of fluorescent probe with benzyl borate was designed for monitoring ONOO–.•The probe was exhibited fast-response, high sensitivity towards ONOO–.•The probe has been used for biological imaging of exogenous and endogenous ONOO–. Peroxynitrite (ONOO–) is one of the species of reactive nitrogen (RNS), which plays an important role in antibacterial activity and signal transduction and other physiological and pathological processes. In this paper, based on the benzyl borate group, a new fluorescent probe capable of detecting ONOO– with high selectivity and sensitivity is designed, and the possible mechanism of the interaction between probe and ONOO– is proposed. The probe shows high fluorescence response to ONOO– in a wide pH range (7.0–11.5). Moreover, the probe exhibit good permeability, and the content of ONOO– in cancer cells and normal cells was successfully monitored.
ISSN:1386-1425
1873-3557
DOI:10.1016/j.saa.2020.119398