Anti-diabetic drugs recent approaches and advancements

• Published in: Bioorganic & medicinal chemistry Vol. 28; no. 5; p. 115263
• Main Authors: Dowarah, Jayanta, Singh, Ved Prakash
• Format: Journal Article
• Language: English
• Published: England 01.03.2020
• Subjects: Diabetes Mellitus - drug therapy; Diabetes Mellitus - metabolism; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacology; Molecular Structure; Structure-Activity Relationship; Anti-diabetic drugs; Glucose; PPAR; SAR; Insulin; Diabetes mellitus
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/j.bmc.2019.115263

Diabetes is one of the major diseases worldwide and is the third leading cause of death in the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control glucose levels in the blood. Most of the drugs are administered orally, except for a few of them, such as insulin, exenatide, and pramlintide. In this review, we are going to discuss seven major types of anti-diabetic drugs: Peroxisome proliferator-activated receptor (PPAR) agonist, protein tyrosine phosphatase 1B (PTP1B) inhibitors, aldose reductase inhibitors, α-glucosidase inhibitors, dipeptidyl peptidase IV (DPP-4) inhibitors, G protein-coupled receptor (GPCR) agonists and sodium-glucose co-transporter (SGLT) inhibitors. Here, we are also discussing some of the recently reported anti-diabetic agents with its multi-target pharmacological actions. This review summarises recent approaches and advancement in anti-diabetes treatment concerning characteristics, structure-activity relationships, functional mechanisms, expression regulation, and applications in medicine.