Severe preeclampsia: Are hemostatic and inflammatory parameters associated?

• Published in: Clinica chimica acta Vol. 427; pp. 65 - 70
• Main Authors: Pinheiro, Melina B., Carvalho, Maria G., Martins-Filho, Olindo A., Freitas, Letícia G., Godoi, Lara C., Alpoim, Patrícia N., Gomes, Karina B., Dusse, Luci M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2014
• Subjects: Adult; Biomarkers - blood; Cytokines - blood; D-Dimer; Female; Fibrin Fibrinogen Degradation Products - analysis; Hemostasis; Humans; Inflammation - blood; Inflammatory cytokines; PAI-1; Plasminogen Activator Inhibitor 1 - blood; Pre-Eclampsia - blood; Pre-Eclampsia - immunology; Pre-Eclampsia - pathology; Preeclampsia; Pregnancy; Young Adult; PAI-1; Inflammatory cytokines; D-Dimer; Preeclampsia
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2013.09.050

Preeclampsia (PE) is characterized by hypertension and proteinuria. A predisposition to endothelial dysfunction, which may trigger abnormal activation of the hemostatic and/or inflammatory systems, is thought to play a crucial part in pathogenesis of PE. We investigated the relationship between hemostatic and inflammatory parameters in women with severe PE. D-Dimer, PAI-1, IL-8, IL-6, TNF-α, and IFN-γ concentrations were measured in 59 pregnant women with severe PE (sPE), 49 normotensive pregnant and 48 non-pregnant women. D-Dimer and PAI-1 were higher in women with sPE compared to normotensive pregnant and non-pregnant women. IL-8, IL-6, and IFN-γ also were higher in women with sPE compared to normotensive pregnant women. However, only IL-6 and IFN-γ were higher in women with sPE compared to non-pregnant women. Moreover, D-Dimer and PAI-1 showed an elevated area under ROC curve proving to be excellent for discriminating sPE. Correlation analysis showed a weak correlation between D-Dimer and IL-8 and between PAI-1 and IFN-γ in sPE. D-Di and PAI-1 concentrations showed to be an important tool for monitoring sPE. •Severe preeclampsia is associated with high levels of D-Dimer and PAI-1.•IL-8, IL-6, and IFN-γ were higher in severe preeclampsia.•D-Dimer and PAI-1 showed to be excellent for discriminating sPE.