Inhibition of precancerous lesions development in kidneys by chrysin via regulating hyperproliferation, inflammation and apoptosis at pre clinical stage

• Published in: Archives of biochemistry and biophysics Vol. 606; pp. 1 - 9
• Main Authors: Rashid, Summya, Nafees, Sana, Vafa, Abul, Afzal, Shekh Muhammad, Ali, Nemat, Rehman, Muneeb U., Hasan, Syed Kazim, Siddiqi, Aisha, Barnwal, Preeti, Majed, Ferial, Sultana, Sarwat
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.09.2016
• Subjects: Animals; Anticarcinogenic Agents - chemistry; Antioxidants - chemistry; Apoptosis; Carcinogenesis; Cell Proliferation; Chrysin; Ferric Compounds; Flavonoids - chemistry; Gene Expression Regulation, Neoplastic; Hyper proliferation; Inflammation; Kidney - pathology; Kidney Neoplasms - physiopathology; Kidney Neoplasms - prevention & control; Lipid Peroxidation; Male; Nitrilotriacetic Acid - analogs & derivatives; Oxidative Stress; Precancerous Conditions - chemically induced; Precancerous Conditions - physiopathology; Rats; Rats, Wistar; Renal cell carcinoma; ROS; Up-Regulation; NADPH; GSSG; DTNB; CH; Inflammation; CDNB; Hyper proliferation; GR; MDA; DEN; EDTA; GPx; BSA; LDH; TBA; Chrysin; Renal cell carcinoma; Fe-NTA; ROS; CAT; BUN; GSH; Apoptosis

Chrysin (CH) is natural, biologically active compound, belongs to flavoniod family and possesses diverse pharmacological activities as anti-inflammatory, anti-oxidant and anti-cancer. It is found in many plants, honey and propolis. In the present study, we investigated the chemopreventive efficacy o...