Interactions of selected gold(III) complexes with DNA G quadruplexes

The interactions of three representative gold(III) complexes with human telomeric DNA sequences were analysed using a variety of biophysical methods, including DNA melting, circular dichroism, SPR and ESI MS; remarkable interactions were highlighted for all tested complexes, although they were assoc...

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Published inDalton transactions : an international journal of inorganic chemistry Vol. 44; no. 8; pp. 3633 - 3639
Main Authors Gratteri, P, Massai, L, Michelucci, E, Rigo, R, Messori, L, Cinellu, M A, Musetti, C, Sissi, C, Bazzicalupi, C
Format Journal Article
LanguageEnglish
Published England 28.02.2015
Subjects
Affinity
Binding
Circular Dichroism
Circularity
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Deoxyribonucleic acid
Dichroism
G-Quadruplexes
Gene sequencing
Gold - chemistry
Human
Humans
Melting
Nucleic Acid Conformation
Spectrometry, Mass, Electrospray Ionization
Surface Plasmon Resonance
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Summary:The interactions of three representative gold(III) complexes with human telomeric DNA sequences were analysed using a variety of biophysical methods, including DNA melting, circular dichroism, SPR and ESI MS; remarkable interactions were highlighted for all tested complexes, although they were associated to significantly different binding profiles. The most interesting compound was Auoxo6, a dinuclear gold(III) complex, which beyond manifesting a conspicuous binding affinity for the G-quadruplex conformation, turned out to be very effective in inducing a non-canonical secondary structure. These findings may clear the way for novel biological and pharmacological applications of this class of metal compounds.
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ISSN:1477-9226
1477-9234
DOI:10.1039/c4dt02698e