Concentration of hs-Troponin in small cohort of transgender patients

• Published in: Clinica chimica acta Vol. 539; pp. 66 - 69
• Main Authors: Boone, Stephen, Peacock, W. Frank, Wu, Alan H.B., Jaffe, Allan, Christenson, Robert H., Ettner, Frederic M., Dadkhah, Shahriar
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2023
• Subjects: Adult; Biomarkers; Blood Coagulation Tests; Cardiac biomarkers; Female; High-sensitivity troponin; Humans; Limit of Detection; Male; Transgender Persons; Troponin; Troponin I; Troponin T; Transgender; Troponin; High-sensitivity troponin; Cardiac biomarkers
• ISSN: 0009-8981; 1873-3492; 1873-3492
• DOI: 10.1016/j.cca.2022.12.003

•Little is known about the impact of sex-hormone therapy on hs-Tn in transgender patients.•Mean hs-Tn concentrations were similar in transgender women and transgender men, though analysis was limited by small sample size.•Further study on this vulnerable population underrepresented in troponin research is needed. Sex-differences in high sensitivity troponin (hs-Tn) concentrations are well established. There is, however, limited data to guide interpretation of hs-Tn in transgender patients, particularly those receiving gender-affirming hormone therapy. Our purpose was to evaluate troponin testing in transgender patients. Transgender adults attending a routine clinic visit provided demographic data, medical history, and venous blood samples. Patients with congestive heart failure or chronic kidney disease were excluded. hs-Tn was measured using the Architect Stat High Sensitivity Troponin-I (Abbott), Access 2 hsTnI (Beckman Coulter), and Elecsys Troponin T Gen 5 STAT (Roche) assays. hs-Tn below the limit of detection (LOD) is reported as the lower limit of detection (LLOD) Of 63 subjects, 76 % were transgender women. We found no significant difference in median hs-Tn concentrations or proportions of hs-Tn > LOD. In this cohort of stable transgender patients without CHF or CKD, we did not observe differences in hs-Tn concentrations between transgender women and transgender men. Meaningful conclusions are limited owing to inadequate sample size and population differences. Further research on hs-troponin concentrations in this underrepresented, vulnerable population is needed.