Copper-catalyzed aerobic oxidative amination of C(sp 3 )–H bonds: synthesis of imidazo[1,5-a]pyridines

Copper-catalyzed synthesis of imidazo[1,5- a ]pyridine-1-carboxylates through oxidative amination of C(sp 3 )–H bonds under mild aerobic conditions with broad substrate scope is described. Use of naturally abundant air as the sole oxidant was found to be efficient and selective. The present protocol...

Full description

Saved in:
Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 13; no. 20; pp. 5602 - 5607
Main Authors Chandra Mohan, Darapaneni, Nageswara Rao, Sadu, Ravi, Chitrakar, Adimurthy, Subbarayappa
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 28.05.2015
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
FUNCTIONALIZATION
PALLADIUM
ANNULATION
COMPLEXES
EFFICIENT SYNTHESIS
PYRROLE SYNTHESIS
ALDEHYDES
C-H ACTIVATION
CYCLIZATION
MOLECULAR-OXYGEN
Online AccessGet full text

Cover

More Information
Summary:Copper-catalyzed synthesis of imidazo[1,5- a ]pyridine-1-carboxylates through oxidative amination of C(sp 3 )–H bonds under mild aerobic conditions with broad substrate scope is described. Use of naturally abundant air as the sole oxidant was found to be efficient and selective. The present protocol is also applicable for direct synthesis of functionalized imidazo[1,5- a ]pyridines from amino acid derivatives.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/C5OB00381D