Aptamer-functionalized DNA microgels: a strategy towards selective anticancer therapeutic systems

DNA microgels of oligonucleotides and polymers were constructed via a combination of DNA complementarity and photo-initiated free radical polymerization. The DNA microgels did not feature the conventional core-shell structure but were instead based on the copolymers of N-isopropylacrylamide and acry...

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Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 4; no. 32; pp. 5446 - 5454
Main Authors Wang, Yitong, Yan, Miaomiao, Xu, Lu, Zhao, Wenrong, Wang, Xiaolin, Dong, Shuli, Hao, Jingcheng
Format Journal Article
LanguageEnglish
Published England 01.01.2016
Subjects
Cancer
Core-shell structure
Crosslinking
Deoxyribonucleic acid
Drug delivery systems
Materials selection
Microgels
Therapy
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Summary:DNA microgels of oligonucleotides and polymers were constructed via a combination of DNA complementarity and photo-initiated free radical polymerization. The DNA microgels did not feature the conventional core-shell structure but were instead based on the copolymers of N-isopropylacrylamide and acrylamide and DNA crosslinks. By incorporating the aptamer-functionalized moieties, the AptMG-Dox system was demonstrated to possess excellent biocompatibility and highly selective killing efficacy for target cancer cells via stimuli-responsiveness, which could provide immense potential as an intelligent drug delivery carrier for targeted cancer therapy.
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ISSN:2050-750X
2050-7518
DOI:10.1039/c6tb01224h