Ocular Manifestations and Outcomes in Children With Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Comparison With Adult Patients

• Published in: American journal of ophthalmology Vol. 256; pp. 108 - 117
• Main Authors: Chen, Yueh-Ling, Tsai, Tsung-Ying, Pan, Li-Yen, Tsai, Yueh-Ju, Chen, Shin-Yi, Hsiao, Ching-Hsi, Yeh, Lung-Kun, Tan, Hsin-Yuan, Chen, Hung-Chi, Hung, Kuo-Hsuan, Quan, Wuyong, Chen, Chun-Bing, Chung, Wen-Hung, Ma, David Hui-Kang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2023
• Subjects: Adult; Anti-Bacterial Agents - therapeutic use; Child; Dry Eye Syndromes - diagnosis; Dry Eye Syndromes - drug therapy; Dry Eye Syndromes - etiology; Follow-Up Studies; Humans; Retrospective Studies; Stevens-Johnson Syndrome - complications; Stevens-Johnson Syndrome - diagnosis; Stevens-Johnson Syndrome - drug therapy
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/j.ajo.2023.08.009

To compare the clinical features and visual outcomes in children and adults with Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Retrospective comparative case series. This retrospective study included 280 eyes of 140 patients (35 children and 105 adults) with SJS/TEN treated between 2010 and 2020. The primary outcome measures were the final best-corrected visual acuity (BCVA) and severity of dry eye. The secondary outcome measure was the medical and surgical therapies used. Among 64 eyes of children recruited in the study, acute ocular involvement was found in 58 eyes (90.6%). The chronic score in pediatric patients was significantly higher than that in adult patients (P = .004). The use of antibiotics/nonsteroidal anti-inflammatory drugs (NSAIDs) and Mycoplasma infection were the more common etiologies in children. In all, 75% of eyes in children maintained a visual acuity of 20/40 or better at a mean follow-up time of 4.3 years. The severity of dryness was comparable between the child and adult groups. The proportion of eyes undergoing amniotic membrane and oral mucosa transplantation was significantly higher in children than in adults in the chronic stage, reflecting that children exhibit much more severe complications. Although pediatric SJS/TEN patients have more severe ocular complications than adults, most children maintain long-term good vision. Early intervention and aggressive treatment help to preserve vision.