Neoplastic Transformation of Rat Thymic Cells Induced in vitro by Gross Leukemia Virus

Cultures of embryonal rat thymus infected initially with Gross leukemia virus have, at the present time, abundantly replicated infectious virus particles for 20 months. Cells from these cultures, after 3 months in vitro, displayed morphological changes and induced formation of tumors upon isotranspl...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 155; no. 3762; pp. 585 - 587
Main Author Ioachim, Harry L.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 03.02.1967
Subjects
AKR murine leukemia virus
Animals
Cultured cells
Epithelioid cells
Histology
Kidneys
Leukemia
Lymphocytes
Microscopy, Electron
Neoplasm Transplantation
Rats
Thymus Gland - pathology
Tissue grafting
Tumors
Virions
Viruses
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Summary:Cultures of embryonal rat thymus infected initially with Gross leukemia virus have, at the present time, abundantly replicated infectious virus particles for 20 months. Cells from these cultures, after 3 months in vitro, displayed morphological changes and induced formation of tumors upon isotransplantation. The tumors were serially transplantable, and subsequent transplants continue to carry the initial Gross leukemia virus.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.155.3762.585