Impact of ZrO2 Content on the Formation of Sr-Enriched Phosphates in Al2O3/ZrO2 Nanocomposites for Bone Tissue Engineering

This study investigates the profound impact of the ZrO2 inclusion volume on the characteristics of Al2O3/ZrO2 nanocomposites, particularly influencing the formation of calcium phosphates on the surface. This research, aimed at advancing tissue engineering, prepared nanocomposites with 5, 10, and 15...

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Published inMaterials Vol. 17; no. 8; p. 1893
Main Authors Nunes, Fabio Caixeta, Santos, Sarah Ingrid Pinto, Colnago, Luiz Alberto, Hammer, Peter, Ferreira, Julieta Adriana, Ambrósio, Carlos Eduardo, Pallone, Eliria Maria
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.04.2024
Subjects
alumina-zirconia
Aluminum oxide
Animal sciences
Biocompatibility
Biological activity
biomaterial
Biomedical materials
Biomimetics
Body fluids
Bones
Calcium phosphates
Fourier transforms
Nanocomposites
Nanostructured materials
Regeneration (physiology)
Spectrum analysis
Stem cells
Strontium
Surface treatment
Tissue engineering
Zirconium dioxide
Zoology
United States > US
Japan
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Summary:This study investigates the profound impact of the ZrO2 inclusion volume on the characteristics of Al2O3/ZrO2 nanocomposites, particularly influencing the formation of calcium phosphates on the surface. This research, aimed at advancing tissue engineering, prepared nanocomposites with 5, 10, and 15 vol% ZrO2, subjecting them to chemical surface treatment for enhanced calcium phosphate deposition sites. Biomimetic coating with Sr-enriched simulated body fluid (SBF) further enhanced the bioactivity of nanocomposites. While the ZrO2 concentration heightened the oxygen availability on nanocomposite surfaces, the quantity of Sr-containing phosphate was comparatively less influenced than the formation of calcium phosphate phases. Notably, the coated nanocomposites exhibited a high cell viability and no toxicity, signifying their potential in bone tissue engineering. Overall, these findings contribute to the development of regenerative biomaterials, holding promise for enhancing bone regeneration therapies.
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ISSN:1996-1944
1996-1944
DOI:10.3390/ma17081893