Dopamine in the rodent tail of striatum regulates behavioral variability in response to threatening novel objects

Mice display variability in fear-like responses to many external salient events, such as encountering unexpected novel objects, but the neural basis of this variability has been unclear. Akiti et al. (2022) demonstrate that dopamine in the tail of the rodent striatum predicts and regulates salience-...

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Bibliographic Details
Published inNeuron (Cambridge, Mass.) Vol. 110; no. 22; pp. 3653 - 3655
Main Authors Pai, Julia, Monosov, Ilya E
Format Journal Article
LanguageEnglish
Published United States 16.11.2022
Subjects
Animals
Corpus Striatum
Dopamine
Mice
Neostriatum
Rodentia
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Summary:Mice display variability in fear-like responses to many external salient events, such as encountering unexpected novel objects, but the neural basis of this variability has been unclear. Akiti et al. (2022) demonstrate that dopamine in the tail of the rodent striatum predicts and regulates salience-related variability in individuals' behavioral responses to unexpected novel objects.
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ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2022.10.019