Association between non-variceal spontaneous portosystemic shunt and outcomes after TIPS in cirrhosis

• Published in: Digestive and liver disease Vol. 50; no. 12; pp. 1315 - 1323
• Main Authors: He, Chuangye, Lv, Yong, Wang, Zhengyu, Guo, Wengang, Tie, Jun, Li, Kai, Niu, Jing, Zuo, Luo, Yu, Tianlei, Yuan, Xulong, Chen, Hui, Wang, Qiuhe, Liu, Haibo, Bai, Wei, Wang, Enxing, Xia, Dongdong, Luo, Bohan, Li, Xiaomei, Yuan, Jie, Han, Na, Zhu, Ying, Wang, Jianhong, Yin, Zhanxin, Fan, Daiming, Han, Guohong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.12.2018
• Subjects: Cirrhosis; Hepatic encephalopathy; Spontaneous portosystemic shunt; Transjugular intrahepatic portosystemic shunt; Cirrhosis; Spontaneous portosystemic shunt; Transjugular intrahepatic portosystemic shunt; Hepatic encephalopathy
• ISSN: 1590-8658; 1878-3562
• DOI: 10.1016/j.dld.2018.05.022

Whether pre-existing nonvariceal spontaneous portosystemic shunts (SPSSs) in cirrhotic patients affect outcomes after transjugular intrahepatic portosystemic shunt (TIPS) and whether they need to be closed remains unclear. To assess the effects of the presence or embolization of SPSSs on outcomes after TIPS for cirrhosis. From January 2004 to December 2014, 903 consecutive cirrhotic patients who underwent TIPS in a tertiary-care center were included, of which 715 patients had no SPSS (N-SPSS group), 144 patients had an SPSS without embolization (SPSS group), and 44 had an SPSS with embolization (SPSS + E group). During a median follow-up period of 27.7 months, 368 (41%) patients experienced overt hepatic encephalopathy (OHE), 256 (28%) experienced clinical relapse, 164 (18%) developed shunt dysfunction, and 379 (42%) died. The SPSS group had a higher risk of OHE compared with the N-SPSS and SPSS + E groups (adjusted HR [95%CI]: N-SPSS vs SPSS vs SPSS + E: 1 vs 1.36 [1.06–1.75] vs 0.77 [0.46–1.29]; p = 0.027). In stratification analysis, a higher risk of OHE was only observed in patients with a large SPSS (SPSS diameter ≥6 mm) but not a small SPSS. Additionally, SPSS embolization was associated with a lower risk of OHE among patients with a large SPSS (adjust HR = 0.51; 95% CI: 0.29–0.91; p = 0.034). The risks of clinical relapse (p = 0.584), shunt dysfunction (p = 0.267), and mortality (p = 0.4743) did not significantly differ among groups. Among cirrhotic patients undergoing TIPS, a pre-existing large SPSS was associated with a higher risk of OHE, which could be decreased by SPSS embolization. There was no clear association between the presence/embolization of an SPSS and post-TIPS clinical relapse, shunt dysfunction or mortality.