Unraveling the Architecture of Classic Hodgkin Lymphoma One Cell at a Time
Aoki and colleagues have utilized single-cell RNA sequencing and imaging mass cytometry to describe the landscape of reactive, nonmalignant immune-cell populations present in classic Hodgkin lymphoma (cHL), and delineate their spatial proximity to malignant Hodgkin-Reed-Sternberg cells. From this st...
Saved in:
Published in | Cancer discovery Vol. 10; no. 3; pp. 342 - 344 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
01.03.2020
|
Online Access | Get full text |
Cover
Loading…
Summary: | Aoki and colleagues have utilized single-cell RNA sequencing and imaging mass cytometry to describe the landscape of reactive, nonmalignant immune-cell populations present in classic Hodgkin lymphoma (cHL), and delineate their spatial proximity to malignant Hodgkin-Reed-Sternberg cells. From this study, they have identified a LAG3-expressing Tr1-type Treg cell population as prevalent mainly in MHC-II-negative cHL, implying a potential functional relationship underlying the differential responsiveness of MHC-II-negative versus MHC-II-positive cHLs to immunotherapy.
. |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1 |
ISSN: | 2159-8274 2159-8290 |
DOI: | 10.1158/2159-8290.CD-19-1538 |