Unraveling the Architecture of Classic Hodgkin Lymphoma One Cell at a Time

Aoki and colleagues have utilized single-cell RNA sequencing and imaging mass cytometry to describe the landscape of reactive, nonmalignant immune-cell populations present in classic Hodgkin lymphoma (cHL), and delineate their spatial proximity to malignant Hodgkin-Reed-Sternberg cells. From this st...

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Bibliographic Details
Published inCancer discovery Vol. 10; no. 3; pp. 342 - 344
Main Authors Fisher, Daniel A C, Oh, Stephen T
Format Journal Article
LanguageEnglish
Published United States 01.03.2020
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Summary:Aoki and colleagues have utilized single-cell RNA sequencing and imaging mass cytometry to describe the landscape of reactive, nonmalignant immune-cell populations present in classic Hodgkin lymphoma (cHL), and delineate their spatial proximity to malignant Hodgkin-Reed-Sternberg cells. From this study, they have identified a LAG3-expressing Tr1-type Treg cell population as prevalent mainly in MHC-II-negative cHL, implying a potential functional relationship underlying the differential responsiveness of MHC-II-negative versus MHC-II-positive cHLs to immunotherapy. .
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ISSN:2159-8274
2159-8290
DOI:10.1158/2159-8290.CD-19-1538