Current Concepts in the Diagnosis and Management of Pneumocystis Pneumonia in Solid Organ Transplantation

Pneumocystis infection manifests predominantly as an interstitial pneumonia in immunocompromised patients. Diagnostic testing in the appropriate clinical context can be highly sensitive and specific and involves radiographic imaging, fungal biomarkers, nucleic acid amplification, histopathology, and...

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Bibliographic Details
Published inInfectious disease clinics of North America Vol. 37; no. 3; p. 617
Main Authors Trubin, Paul A, Azar, Marwan M
Format Journal Article
LanguageEnglish
Published United States 01.09.2023
Subjects
Pneumonia
Solid organ transplantation
PCP
Immunocompromised
Pneumocystis jirovecii
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Summary:Pneumocystis infection manifests predominantly as an interstitial pneumonia in immunocompromised patients. Diagnostic testing in the appropriate clinical context can be highly sensitive and specific and involves radiographic imaging, fungal biomarkers, nucleic acid amplification, histopathology, and lung fluid or tissue sampling. Trimethoprim-sulfamethoxazole remains the first-choice agent for treatment and prophylaxis. Investigation continues to promote a deeper understanding of the pathogen's ecology, epidemiology, host susceptibility, and optimal treatment and prevention strategies in solid organ transplant recipients.
ISSN:1557-9824
DOI:10.1016/j.idc.2023.03.005