Medical Treatment of Overactive Bladder

Overactive bladder is a disruptive urinary condition composed of urgency, frequency, and nocturia, which affects a large proportion of men and women. Symptoms are often associated with a decreased quality of life. After optimizing behavioral strategies, pharmacologic intervention is the next conside...

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Bibliographic Details
Published inUrologic clinics of North America Vol. 49; no. 2; pp. 249 - 261
Main Authors Loloi, Justin, Clearwater, Whitney, Schulz, Alison, Suadicani, Sylvia O., Abraham, Nitya
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2022
Subjects
Antimuscarinic
Beta-agonist
Combined Modality Therapy
Female
Humans
Male
Muscarinic Antagonists - therapeutic use
Overactive bladder
Pharmacotherapy
Quality of Life
Urge urinary incontinence
Urinary Bladder, Overactive - drug therapy
Pharmacotherapy
Beta-agonist
Overactive bladder
Antimuscarinic
Urge urinary incontinence
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Summary:Overactive bladder is a disruptive urinary condition composed of urgency, frequency, and nocturia, which affects a large proportion of men and women. Symptoms are often associated with a decreased quality of life. After optimizing behavioral strategies, pharmacologic intervention is the next consideration for treatment. Therapeutic agents consist primarily of antimuscarinic and β-agonist medications, as well as off-label use of antidepressants in some cases. These medications, although effective, can be associated with considerable adverse side effects. Combination therapies along with novel therapeutics and drug targets are under investigation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0094-0143
1558-318X
DOI:10.1016/j.ucl.2021.12.005