Vitamin K deficiency does not functionally impair skeletal metabolism of laying hens and their progeny

The purpose of this research was to determine the effect of vitamin K deficiency on indices of skeletal metabolism in laying hens, developing embryos and young growing chickens. Laying hens were fed a vitamin K-deficient diet for 28 wk, which resulted in impaired blood clotting and reduced bone gamm...

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Published inThe Journal of nutrition Vol. 124; no. 3; pp. 371 - 377
Main Authors LAVELLE, P. A, LLOYD, Q. P, GAY, C. V, LEACH, R. M
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Society for Nutritional Sciences 01.03.1994
Subjects
1-Carboxyglutamic Acid - metabolism
Animals
Biological and medical sciences
Blood Coagulation - physiology
Bone and Bones - metabolism
Calcium - metabolism
Chick Embryo - metabolism
Chickens - growth & development
Chickens - metabolism
Female
Fundamental and applied biological sciences. Psychology
Osteocalcin - metabolism
Reproduction - physiology
Skeleton and joints
Vertebrates: osteoarticular system, musculoskeletal system
Vitamin K Deficiency - metabolism
Embryonic development
Embryo
Osteocalcin
Calcium
Vitamin deficiency
Metabolism
Postnatal development
Young animal
Vertebrata
Chicken
Skeleton
Bone
Aves
Vitamin K
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Summary:The purpose of this research was to determine the effect of vitamin K deficiency on indices of skeletal metabolism in laying hens, developing embryos and young growing chickens. Laying hens were fed a vitamin K-deficient diet for 28 wk, which resulted in impaired blood clotting and reduced bone gamma-carboxyglutamic acid (Gla) concentration compared with vitamin K-sufficient hens. However, this treatment did not influence egg production, eggshell deposition or other reproductive performance criteria. Vitamin K-deficient embryos were able to mobilize sufficient quantities of calcium for normal skeletal development, although they exhibited severe reduction in blood clotting and bone Gla concentration. Similar results were obtained from progeny of both vitamin K-sufficient and -deficient hens fed deficient diets for 4 wk after hatching. These results indicate that a severe reduction in skeletal protein Gla concentration does not interfere with normal development of this tissue.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-3166
1541-6100
DOI:10.1093/jn/124.3.371