One domain to rule them all: "In synapse" reconstitution of core active zone functions

Active zones are colossal and complex molecular machines that transform electrical signals into rapid neurotransmitter secretion. In this issue of Neuron, Tan et al. (2022) elegantly distill central functions of this synaptic apparatus by tethering a small domain of the scaffold RIM near Ca channels...

Full description

Saved in:
Bibliographic Details
Published inNeuron (Cambridge, Mass.) Vol. 110; no. 9; pp. 1435 - 1438
Main Authors Chien, Chun, Dickman, Dion
Format Journal Article
LanguageEnglish
Published United States 04.05.2022
Subjects
Animals
Mice
Mice, Knockout
Neurons
Presynaptic Terminals
Synapses
Synaptic Transmission - physiology
Online AccessGet full text

Cover

More Information
Summary:Active zones are colossal and complex molecular machines that transform electrical signals into rapid neurotransmitter secretion. In this issue of Neuron, Tan et al. (2022) elegantly distill central functions of this synaptic apparatus by tethering a small domain of the scaffold RIM near Ca channels.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
content type line 23
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2022.04.004