Exhaled breath analysis in disease detection

• Published in: Clinica chimica acta Vol. 515; pp. 61 - 72
• Main Authors: Chen, Ting, Liu, Tiannan, Li, Ting, Zhao, Hang, Chen, Qianming
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2021
• Subjects: Disease diagnosis; Exhaled breath; Volatile organic compounds; VOCs; NO; MoO3; UBT; eNO; EBC; CO2; HP; H2S; CEAS; PTR-MS; H2O2; KRT; Exhaled breath; Volatile organic compounds; GC-MS; NMR; Disease diagnosis; SIFT-MS; LC; NH3; SnO2; WO3; PET
• ISSN: 0009-8981; 1873-3492; 1873-3492
• DOI: 10.1016/j.cca.2020.12.036

•Breath analysis is noninvasive, reproducible, and easily available.•Various different and unique ideas, strategies, and devices were used to analyze exhaled breath.•Breath analysis can be used to distinguish patients from healthy subjects to a certain extent.•Breath analysis is a promising screening and diagnosis method. Investigating the use of exhaled breath analysis to diagnose and monitor different diseases has attracted much interest in recent years. This review introduces conventionally used methods and some emerging technologies aimed at breath analysis and their relevance to lung disease, airway inflammation, gastrointestinal disorders, metabolic disorders and kidney diseases. One section correlates breath components and specific diseases, whereas the other discusses some unique ideas, strategies, and devices to analyze exhaled breath for the diagnosis of some common diseases. This review aims to briefly introduce the potential application of exhaled breath analysis for the diagnosis and screening of various diseases, thereby providing a new avenue for the detection of non-invasive diseases.